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Personalizing voriconazole dosing in Chinese hematological patients: CYP2C19 phenotype and albumin-bilirubin grade as key predictors of trough concentrations

PurposeThis retrospective, single-center study aimed to evaluate the genetic and non-genetic factors influencing voriconazole (VRC) trough concentration (Ctrough), efficacy and safety in hematological patients.MethodsMedical records of inpatients were reviewed retrospectively. Univariate and multiva...

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Principais autores: Lin Hu, Xi Tang, Yanfei Li, Juanjuan Huang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
coleção:Frontiers in Pharmacology
Assuntos:
voriconazole
CYP2C19 phenotype
albumin-bilirubin grade
hematological patients
therapeutic drug monitoring
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1667461/full
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