Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic liver diseases, including advanced stages o...

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Detalles Bibliográficos

Autores principales:	Ece Yildiz, Gaby El Alam, Alessia Perino, Antoine Jalil, Pierre-Damien Denechaud, Katharina Huber, Lluis Fajas, Johan Auwerx, Giovanni Sorrentino, Kristina Schoonjans
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2023-03-01
Colección:	eLife
Materias:	BECs liver steatosis BEC-organoids BEC activation cell cycle glycolysis
Acceso en línea:	https://elifesciences.org/articles/81926
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