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Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins

Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. Surface Plasmon Resonance assays have been performed to determine the binding affinity between PDZ domain of wild type hu...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ettore Lo Cascio, Angelo Toto, Gabriele Babini, Flavio De Maio, Maurizio Sanguinetti, Alvaro Mordente, Stefano Della Longa, Alessandro Arcovito
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science (AAAS) 2021-01-01
Schriftenreihe:Computational and Structural Biotechnology Journal
Schlagworte:
SARS-CoV E SLiMs
Human PALS1
Molecular dynamics
Surface Plasmon resonance
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2001037021000866
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