Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins

Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. Surface Plasmon Resonance assays have been performed to determine the binding affinity between PDZ domain of wild type hu...

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Auteurs principaux:	Ettore Lo Cascio, Angelo Toto, Gabriele Babini, Flavio De Maio, Maurizio Sanguinetti, Alvaro Mordente, Stefano Della Longa, Alessandro Arcovito
Format:	Artigo
Langue:	Inglês
Publié:	American Association for the Advancement of Science (AAAS) 2021-01-01
Collection:	Computational and Structural Biotechnology Journal
Sujets:	SARS-CoV E SLiMs Human PALS1 Molecular dynamics Surface Plasmon resonance
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2001037021000866
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