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A bispecific ADC against CCR8 and TNFR2 elicits potent antitumor efficacy

Tumor-infiltrating regulatory T (Ti-Treg) cells play a pivotal role in suppressing antitumor immune responses within tumor microenvironment. Targeted depletion of Treg cells has emerged as a promising strategy to enhance antitumor immunity. However, current approaches such as antibody-drug conjugate...

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Principais autores: Wenxin Li, Quanxiao Li, Qingtong Zhou, Yanling Wu, Ming-Wei Wang, Tianlei Ying
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-12-01
Serier:Medicine in Drug Discovery
Fag:
T-Lymphocytes
Regulatory
Receptors
CCR8 Receptors
Tumor Necrosis Factor
Type II
Online adgang:http://www.sciencedirect.com/science/article/pii/S2590098625000235
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