Shooting two hawks with one arrow: manganese-doped mesoporous carriers coordinate STING activation and enhanced mRNA translation for in situ cytokine delivery

Cytokine mRNAs, such as IL-12, hold significant promise for anti-tumor therapy. However, their effective localized delivery and the prevention of off-target translation remain challenging. To address these challenges, we synthesized manganese-doped organic mesoporous carriers for mRNA delivery (PMSM...

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Detalles Bibliográficos

Principais autores:	Yakai Yan, Liuyi Chen, Yue Wu, Xinrong Qu, Xiang Ma, Xing Sun, Guangya Xiang, Yao Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-04-01
Series:	Materials Today Bio
Assuntos:	Metalloimmunotherapy Manganese-doped mesoporous carriers cGAS-STING pathway mRNA delivery IL-12/IL-15 mRNA Tumor immunotherapy
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S259000642600044X
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