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Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen

We have previously reported that nanoparticles (NPs) loaded with IL-2 and TGF-β and targeted to T cells induced polyclonal T regulatory cells (Tregs) that protected mice from graft-versus-host disease (GvHD). Here, we evaluated whether administration of these NPs during alloantigen immunization coul...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: David A. Horwitz, Ju Hua Wang, Dongin Kim, Chang Kang, Katja Brion, Sean Bickerton, Antonio La Cava
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2024-07-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
(NP) nanoparticle
(GVHD) graft-versus-host disease
(MLR) mixed lymphocyte reaction
(DC) dendritic cell
(Treg) T regulatory cell
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1429335/full
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