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A Genetically Truncated RGD-Containing Peptide rLj-RGD4 Exhibits Potent In Vivo Antitumor Activity via Induction of Multi-Pathway Apoptosis and EGFR-Targeted Signaling Suppression

Although the parental recombinant protein rLj-RGD3 exhibits antitumor activity, it carries immunogenicity risks owing to its large molecular size (13.5 kDa). We generated a genetically truncated mutant, rLj-RGD4 (6.27 kDa, four RGD motifs), which inhibited B16 melanoma cell proliferation, migration,...

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Principais autores: Yuyao Song, Huijie Yan, Yuebin Zhang, Jingyu Zhang, Li Lv, Jihong Wang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Molecules
Fag:
rLj-RGD4 peptide
antitumor activity
apoptosis
internalization
EGFR
Online adgang:https://www.mdpi.com/1420-3049/31/8/1266
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