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Synthesis and Biological Evaluation of Imidazo[2,1-<i>b</i>]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

A novel series of imidazo[2,1-<i>b</i>]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII,...

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Principais autores: Kesari Lakshmi Manasa, Sravya Pujitha, Aaftaab Sethi, Mohammed Arifuddin, Mallika Alvala, Andrea Angeli, Claudiu T. Supuran
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-03-01
coleção:Metabolites
Assuntos:
carbonic anhydrase
hCA I
hCA II
hCA IX
hCA XII
imidazo[2,1-<i>b</i>]thiazole
Acesso em linha:https://www.mdpi.com/2218-1989/10/4/136
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