Synthesis and Biological Evaluation of Imidazo[2,1-<i>b</i>]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors
A novel series of imidazo[2,1-<i>b</i>]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII,...
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| Автори: | , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
MDPI AG
2020-03-01
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| Серія: | Metabolites |
| Предмети: | |
| Онлайн доступ: | https://www.mdpi.com/2218-1989/10/4/136 |
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