VHL-recruiting PROTAC attenuates AKI-CKD transition via simultaneous degradation of Smad3 and stabilization of HIF-2α

Abstract Acute kidney injury (AKI) impairs renal function in the short term and may eventually progress to chronic kidney disease (CKD) in the long term. The activation of Smad3 and an imbalance in hypoxia-inducible factors-α (HIF-α) expression constitute vital mechanisms leading to the AKI-CKD tran...

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Principais autores:	Yuyi Ruan, Dan Wang, Yuzhu Xu, Jiayi Yang, Yutong Chen, Jinjin Fan, Sydney C. W. Tang, Wei Chen, Xin Wang
格式:	Artigo
语言:	Inglês
出版:	Nature Publishing Group 2026-04-01
丛编:	Cell Death and Disease
在线阅读:	https://doi.org/10.1038/s41419-026-08726-w
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