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Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs

Proteolysis-Targeting Chimeras (PROTACs) are a promising new technology in drug development. They have rapidly evolved in recent years, with several of them in clinical trials. While most of these advances have been associated with monovalent protein degraders, bivalent PROTACs have also entered cli...

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Principais autores: Ponien Kou, Elizabeth S. Levy, An D. Nguyen, Donglu Zhang, Shu Chen, Yusi Cui, Xing Zhang, Fabio Broccatelli, Jennifer Pizzano, Jennifer Cantley, Elizabeth Bortolon, Emma Rousseau, Michael Berlin, Peter Dragovich, Vijay Sethuraman
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-08-01
coleção:Pharmaceutics
Assuntos:
PROTAC
liposome
nanoparticle
drug delivery
Acesso em linha:https://www.mdpi.com/1999-4923/15/8/2098
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