In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori

Adenylosuccinate synthetase (AdSS) is an enzyme at regulatory point of purine metabolism. In pathogenic organisms which utilise only the purine salvage pathway, AdSS asserts itself as a promising drug target. One of these organisms is Helicobacter pylori, a wide-spread human pathogen involved in the...

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Autori principali:	Ante Bubić, Natalia Mrnjavac, Igor Stuparević, Marta Łyczek, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Marija Luić, Ivana Leščić Ašler
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2018-01-01
Serie:	Journal of Enzyme Inhibition and Medicinal Chemistry
Soggetti:	Helicobacter pylori adenylosuccinate synthetase enzyme kinetics enzyme inhibition oligomeric state analytical ultracentrifugation
Accesso online:	http://dx.doi.org/10.1080/14756366.2018.1506773
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