Granzyme B cleaves tenascin-C to release its C-terminal domain in rheumatoid arthritis

Rheumatoid arthritis (RA) is a common autoimmune disorder characterized by exacerbated joint inflammation. Despite the well-documented accumulation of the serine protease granzyme B (GzmB) in RA patient biospecimens, little is understood pertaining to its role in pathobiology. In the present study,...

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Autors principals:	Alexandre Aubert, Amy Liu, Martin Kao, Jenna Goeres, Katlyn C. Richardson, Lorenz Nierves, Karen Jung, Layla Nabai, Hongyan Zhao, Gertraud Orend, Roman Krawetz, Philipp F. Lange, Alastair Younger, Jonathan Chan, David J. Granville
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical investigation 2024-12-01
Col·lecció:	JCI Insight
Matèries:	Autoimmunity Inflammation
Accés en línia:	https://doi.org/10.1172/jci.insight.181935
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