Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers
The collagen-binding receptor tyrosine kinase DDR1 (discoidin domain receptor 1) is a drug target for a wide range of human diseases, but the molecular mechanism of DDR1 activation is poorly defined. Here we co-expressed different types of signalling-incompetent DDR1 mutants (‘receiver’) with functi...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications Ltd
2017-06-01
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| Serier: | eLife |
| Fag: | |
| Online adgang: | https://elifesciences.org/articles/25716 |
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