Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport ManganeseSummary

Background & Aims: SLC11A2 (DMT1) and SLC40A1 (ferroportin) are essential for dietary iron absorption, but their role in manganese transport is debated. SLC30A10 deficiency causes severe manganese excess due to loss of gastrointestinal manganese excretion. Patients are treated with chelators but...

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Detalhes bibliográficos

Principais autores:	Milankumar Prajapati, Jared Z. Zhang, Grace S. Chong, Lauren Chiu, Courtney J. Mercadante, Heather L. Kowalski, Olga Antipova, Barry Lai, Martina Ralle, Brian P. Jackson, Tracy Punshon, Shuling Guo, Mariam Aghajan, Thomas B. Bartnikas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-01-01
coleção:	Cellular and Molecular Gastroenterology and Hepatology
Assuntos:	Absorption Homeostasis Metal
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352345X2500030X
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