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WNT signaling contributes to the extrahepatic bile duct proliferative response to obstruction in mice

Biliary obstruction and cholangiocyte hyperproliferation are important features of cholangiopathies affecting the large extrahepatic bile duct (EHBD). The mechanisms underlying obstruction-induced cholangiocyte proliferation in the EHBD remain poorly understood. Developmental pathways, including WNT...

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Principais autores: Ashley N. Calder, Mirabelle Q. Peter, John W. Tobias, Nureen H. Mohamad Zaki, Theresa M. Keeley, Timothy L. Frankel, Linda C. Samuelson, Nataliya Razumilava
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2025-01-01
Serier:JCI Insight
Fag:
Hepatology
Online adgang:https://doi.org/10.1172/jci.insight.181857
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