Insights on the comparative affinity of ribonucleic acids with plant-based beta carboline alkaloid, harmine: Spectroscopic, calorimetric and computational evaluation

Small molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the clover leaf tRNAphe, and the double-stranded A-f...

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Detalhes bibliográficos

Principais autores:	Paromita Sarkar, Priyanka Gopi, Prateek Pandya, Samaresh Paria, Maidul Hossain, Manzer H. Siddiqui, Saud Alamri, Kakali Bhadra
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-07-01
coleção:	Heliyon
Assuntos:	Harmine Beta-carboline alkaloid Ribonucleic acids RNAs Molecular docking Molecular dynamics Principal component analysis (PCA)
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405844024102149
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