Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens

Abstract CRISPR‐Cas9 screens facilitate the discovery of gene functional relationships and phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole‐genome CRISPR screens aimed at identifying cancer‐specific genetic dependencies across human cell lines. A...

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Podrobná bibliografie

Hlavní autoři:	Arshia Zernab Hassan, Henry N Ward, Mahfuzur Rahman, Maximilian Billmann, Yoonkyu Lee, Chad L Myers
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2023-11-01
Edice:	Molecular Systems Biology
Témata:	auto‐encoder gene co‐essentiality network normalization robust principal component analysis unsupervised dimensionality reduction
On-line přístup:	https://doi.org/10.15252/msb.202311657
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