Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens

Abstract CRISPR‐Cas9 screens facilitate the discovery of gene functional relationships and phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole‐genome CRISPR screens aimed at identifying cancer‐specific genetic dependencies across human cell lines. A...

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Detalhes bibliográficos

Principais autores:	Arshia Zernab Hassan, Henry N Ward, Mahfuzur Rahman, Maximilian Billmann, Yoonkyu Lee, Chad L Myers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2023-11-01
coleção:	Molecular Systems Biology
Assuntos:	auto‐encoder gene co‐essentiality network normalization robust principal component analysis unsupervised dimensionality reduction
Acesso em linha:	https://doi.org/10.15252/msb.202311657
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