In Silico Analysis of Tetrodotoxin Binding in Voltage-Gated Sodium Ion Channels from Toxin-Resistant Animal Lineages

Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in homologous residues associated with reductions in...

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Главные авторы:	Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-11-01
Серии:	Marine Drugs
Предметы:	marine toxin voltage-gated ion channels structure tetrodotoxin TTX toxin resistance
Online-ссылка:	https://www.mdpi.com/1660-3397/20/11/723
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