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Development of New Antimycobacterial Sulfonyl Hydrazones and 4-Methyl-1,2,3-thiadiazole-Based Hydrazone Derivatives

Fifteen 4-methyl-1,2,3-thiadiazole-based hydrazone derivatives <b>3a</b>–<b>d</b> and sulfonyl hydrazones <b>5a</b>–<b>k</b> were synthesized. They were characterized by <sup>1</sup>H-NMR, <sup>13</sup>C NMR, and HRMS. <i>Mycobacterium tuberculosis</i> strain H37Rv was used to assess their antimycob...

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Principais autores: Violina T. Angelova, Tania Pencheva, Nikolay Vassilev, Elena K-Yovkova, Rositsa Mihaylova, Boris Petrov, Violeta Valcheva
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-04-01
סדרה:Antibiotics
נושאים:
antimycobacterial activity
ADME/Tox predictions
cytotoxicity
hydrazide-hydrazone derivatives
sulfonyl hydrazone derivatives
molecular docking
גישה מקוונת:https://www.mdpi.com/2079-6382/11/5/562
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