SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART) [version 2; peer review: 2 approved, 1 approved with reservations]

Background Even on the best antimalarial treatments (injectable artesunate) African children with severe malaria have poor outcomes with most deaths occurring early in the course of hospital admission (<24hours). Lactic acidosis, largely due to impairment of the microcirculatory flow due to parasite...

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Autori principali:	Mainga Hamaluba, Thomas N. Williams, Christabel Mogoka, Luc Kambale Kamavu, Mike Chaponda, Sam Miti, Nick White, Nick Day, Nchafatso Obonyo, Diana M. Gibb, Elizabeth C. George, Arjen Dondorp, Kathryn Maitland, Roisin Connon, A. Sarah Walker, Jonathan Jonathan Gwasupika, Emmanuel Oguda
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wellcome 2024-08-01
Serie:	Wellcome Open Research
Soggetti:	severe malaria adjunctive therapy children Africa clinical trial heparin-like molecule eng
Accesso online:	https://wellcomeopenresearch.org/articles/8-484/v2
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