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SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART) [version 2; peer review: 2 approved, 1 approved with reservations]

Background Even on the best antimalarial treatments (injectable artesunate) African children with severe malaria have poor outcomes with most deaths occurring early in the course of hospital admission (<24hours). Lactic acidosis, largely due to impairment of the microcirculatory flow due to parasite...

Deskribapen osoa

Gorde:
Egile Nagusiak: Mainga Hamaluba, Thomas N. Williams, Christabel Mogoka, Luc Kambale Kamavu, Mike Chaponda, Sam Miti, Nick White, Nick Day, Nchafatso Obonyo, Diana M. Gibb, Elizabeth C. George, Arjen Dondorp, Kathryn Maitland, Roisin Connon, A. Sarah Walker, Jonathan Jonathan Gwasupika, Emmanuel Oguda
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wellcome 2024-08-01
Saila:Wellcome Open Research
Gaiak:
severe malaria
adjunctive therapy
children
Africa
clinical trial
heparin-like molecule
eng
Sarrera elektronikoa:https://wellcomeopenresearch.org/articles/8-484/v2
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