RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

Abstract Background Runt-related transcription factor 1 (RUNX1) plays the roles of an oncogene and an anti-oncogene in epithelial tumours, and abnormally elevated RUNX1 has been suggested to contribute to the carcinogenesis of colorectal cancer (CRC). However, the mechanism remains unclear. Methods...

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Detalhes bibliográficos

Principais autores:	Qingyuan Li, Qiuhua Lai, Chengcheng He, Yuxin Fang, Qun Yan, Yue Zhang, Xinke Wang, Chuncai Gu, Yiqing Wang, Liangying Ye, Lu Han, Xin Lin, Junsheng Chen, Jianqun Cai, Aimin Li, Side Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-08-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	RUNX1 Colorectal cancer KIT Wnt/β-catenin EMT
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-019-1330-9
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