ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition

Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome-scale CRISPR-Cas9 loss-of-function screens in two KRAS mutant pancreati...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Belinda Wang, Elsa Beyer Krall, Andrew James Aguirre, Miju Kim, Hans Ragnar Widlund, Mihir Bhavik Doshi, Ewa Sicinska, Rita Sulahian, Amy Goodale, Glenn Spencer Cowley, Federica Piccioni, John Gerard Doench, David Edward Root, William Chun Hahn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2017-02-01
Edice:	Cell Reports
Témata:	CIC ATXN1L ETS MEK MAPK trametinib KRAS resistance CRISPR-Cas9 cancer
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124717300682
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!