Human Rotaviruses of Multiple Genotypes Acquire Conserved VP4 Mutations during Serial Passage

Human rotaviruses exhibit limited tropism and replicate poorly in most cell lines. Attachment protein VP4 is a key rotavirus tropism determinant. Previous studies in which human rotaviruses were adapted to cultured cells identified mutations in VP4. However, most such studies were conducted using on...

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Autors principals:	Maximilian H. Carter, Jennifer Gribble, Julia R. Diller, Mark R. Denison, Sara A. Mirza, James D. Chappell, Natasha B. Halasa, Kristen M. Ogden
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-06-01
Col·lecció:	Viruses
Matèries:	rotavirus VP4 genotype serial passage culture adaptation
Accés en línia:	https://www.mdpi.com/1999-4915/16/6/978
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