Codice QR

Combined inhibition of polyamine biosynthesis and uptake blocks Candida albicans virulence

ABSTRACT Polyamines, small organic polycations, are essential for life, and cells maintain polyamines via synthesis and uptake. Recently, we identified Hol1 as the high-affinity polyamine transporter in Saccharomyces cerevisiae. Hol1 is a conserved fungal-specific transporter with Candida albicans h...

Descrizione completa

Salvato in:
Autori principali: Arya Vindu, Brendan D. Snarr, Chune Cao, Ronda J. Rolfes, Otto Phanstiel, Michail S. Lionakis, Thomas E. Dever
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2026-01-01
Serie:mBio
Soggetti:
Hol1
polyamine
spermidine
polyamine transport
Candida virulence
DFMO
Accesso online:https://journals.asm.org/doi/10.1128/mbio.03524-25
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi