Pseudo-mutant P53 is a unique phenotype of <i>DNMT3A</i>-mutated pre-leukemia
Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemoresistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hematopoietic stem/progenitor cells (preL-HSPC) and lead to chemoresi...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ferrata Storti Foundation
2022-02-01
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| coleção: | Haematologica |
| Acesso em linha: | https://haematologica.org/article/view/10550 |
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