MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density

Abstract Background Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination of 5’-methylcytosine. Methods Here, we have investi...

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Autors principals:	Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, Stéphanie Le Gras, Isabelle Stoll, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Alfonso Bellacosa, Christian Bronner, Ali Hamiche
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-11-01
Col·lecció:	Journal of Experimental & Clinical Cancer Research
Matèries:	MBD4 MLH1 Mismatch repair Cancer DNA methylation
Accés en línia:	https://doi.org/10.1186/s13046-023-02882-z
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