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Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the Tripterygium wilfordii plant, has been extensively researched for its potential effectiveness in fighting cancer. However, its clinical application has been hindered b...

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Principais autores: Piao Luo, Qian Zhang, Shuo Shen, Yehai An, Lixia Yuan, Yin-Kwan Wong, Sizhe Huang, Shaohui Huang, Jingnan Huang, Guangqing Cheng, Jiahang Tian, Yu Chen, Xiaoyong Zhang, Weiguang Li, Songqi He, Jigang Wang, Qingfeng Du
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co., Ltd. 2023-11-01
coleção:Asian Journal of Pharmaceutical Sciences
Assuntos:
Celastrol
VDAC2
Ferroptosis
Apoptosis
Hepatocellular carcinoma
Liposomes
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1818087623001009
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