Elucidation of a Novel Dual Binding Site on Tubulin: Theoretical Insights and Prospective Hybrid Inhibitors

<b>Background/Objectives:</b> Microtubule-targeting agents remain foundational components of anticancer chemotherapy, yet their clinical utility is constrained by resistance and toxicity. <b>Methods:</b> Here, we present a theoretical exploration of a plausible “dual” binding pocket that spans the α...

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Detalhes bibliográficos

Principais autores:	Dmytro Khylyuk, Oleg M. Demchuk, Rafał Kurczab, Barbara Miroslaw, Monika Wujec
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-12-01
Colecção:	Pharmaceuticals
Assuntos:	α-tubulin dual binding site pironetin todalam covalent inhibitor anticancer activity
Acesso em linha:	https://www.mdpi.com/1424-8247/19/1/3
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