Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Colorectal cancer ranks third in global incidence and second in cancer mortality. Patient‐derived models are irreplaceable for studying tumor biology. We established a human epithelial cell line from a rectal adenocarcinoma overexpressing cancer stem cell marker ALDH1A1, and we investigated the effe...

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主要な著者:	Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2026-06-01
シリーズ:	Molecular Oncology
主題:	aldehyde dehydrogenase colorectal cancer CRISPR‐Cas9 metastasis
オンライン･アクセス:	https://doi.org/10.1002/1878-0261.70215
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