Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Colorectal cancer ranks third in global incidence and second in cancer mortality. Patient‐derived models are irreplaceable for studying tumor biology. We established a human epithelial cell line from a rectal adenocarcinoma overexpressing cancer stem cell marker ALDH1A1, and we investigated the effe...

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Hlavní autoři:	Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-06-01
Edice:	Molecular Oncology
Témata:	aldehyde dehydrogenase colorectal cancer CRISPR‐Cas9 metastasis
On-line přístup:	https://doi.org/10.1002/1878-0261.70215
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