Bone mesenchymal stem cells-derived exosomal miR-509-5p promotes osteogenic differentiation by targeting SFRP1 and activating the Wnt/β-catenin pathway

Abstract Osteogenic differentiation is a critical biological process for bone formation and regeneration. Exosomes, as extracellular vesicles, play vital roles in intercellular communication by transferring bioactive molecules. This study aimed to investigate the role and mechanism of exosomal miRNA...

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Autors principals:	Lihua Liu, Wei Sun, Boya Li, Jiangning Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-01-01
Col·lecció:	Scientific Reports
Matèries:	Bone mesenchymal stem cells Osteogenic differentiation Exosomes MiR-509-5p SFRP1 Wnt/β-catenin pathway
Accés en línia:	https://doi.org/10.1038/s41598-025-33075-7
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