When UDG and hAPE1 Meet Cyclopurines. How (5′<i>R</i>) and (5′<i>S</i>) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?

Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus). CdPus may become a component of clustered DNA lesions (CDL), which are notably unfavorable for the base excision repair...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2021-08-01
Цуврал:	Molecules
Нөхцлүүд:	5′,8-cyclo-2′-deoxyadenosine (cdA) 5′,8-cyclo-2′-deoxyguanosine (cdG) tandem lesions base excision repair uracil-DNA glycosylase human AP site endonuclease 1
Онлайн хандалт:	https://www.mdpi.com/1420-3049/26/17/5177
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!