When UDG and hAPE1 Meet Cyclopurines. How (5′<i>R</i>) and (5′<i>S</i>) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?

Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus). CdPus may become a component of clustered DNA lesions (CDL), which are notably unfavorable for the base excision repair...

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Egile Nagusiak:	Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2021-08-01
Saila:	Molecules
Gaiak:	5′,8-cyclo-2′-deoxyadenosine (cdA) 5′,8-cyclo-2′-deoxyguanosine (cdG) tandem lesions base excision repair uracil-DNA glycosylase human AP site endonuclease 1
Sarrera elektronikoa:	https://www.mdpi.com/1420-3049/26/17/5177
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