Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants

Avian H5N1 influenza viruses continue to spread in wild birds and domestic poultry with sporadic infection in humans. Receptor binding specificity changes are a prerequisite for H5N1 viruses and other zoonotic viruses to be transmitted among humans. Previous reported hemagglutinin (HA) mutants from...

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Autori principali:	Xueyong Zhu, Karthik Viswanathan, Rahul Raman, Wenli Yu, Ram Sasisekharan, Ian A. Wilson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2015-11-01
Serie:	Cell Reports
Soggetti:	H5N1 influenza virus hemagglutinin receptor binding specificity transmission crystal structure glycan complex
Accesso online:	http://www.sciencedirect.com/science/article/pii/S221112471501181X
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