Evaluating the clinical impact of routine whole genome sequencing in tuberculosis treatment decisions and the issue of isoniazid mono-resistance

Abstract Background The UK has implemented routine use of whole genome sequencing (WGS) in TB diagnostics. The WHO recommends addition of a fluoroquinolone for isoniazid mono-resistance, so early detection may be of use. The aim of this study was to describe the clinical utility and impact of WGS on...

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Prif Awduron:	Mirae Park, Ajit Lalvani, Giovanni Satta, Onn Min Kon
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2022-04-01
Cyfres:	BMC Infectious Diseases
Pynciau:	Whole genome sequencing Tuberculosis Treatment alteration Turnaround times Isoniazid mono-resistance
Mynediad Ar-lein:	https://doi.org/10.1186/s12879-022-07329-y
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