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Cancer burden in individuals with single versus double pathogenic variants in cancer susceptibility genes

Purpose: As panel testing expands, more individuals with double pathogenic variants (DPVs) in cancer susceptibility genes are likely to be identified. Little is known about the effects of DPVs on cancer phenotype, although this information is crucial for genetic counseling and risk management. We so...

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Principais autores: Nihat B. Agaoglu, Brittany L. Bychkovsky, Carolyn Horton, Min-Tzu Lo, Linda Polfus, Cassidy Carraway, Parichehr Hemyari, Colin Young, Marcy E. Richardson, Rochelle Scheib, Judy E. Garber, Huma Q. Rana
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-01-01
Serier:Genetics in Medicine Open
Fag:
Breast cancer
Genetics
Germline
Hereditary cancer
Multiple pathogenic variants
Online adgang:http://www.sciencedirect.com/science/article/pii/S2949774424009750
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