Cancer burden in individuals with single versus double pathogenic variants in cancer susceptibility genes

Purpose: As panel testing expands, more individuals with double pathogenic variants (DPVs) in cancer susceptibility genes are likely to be identified. Little is known about the effects of DPVs on cancer phenotype, although this information is crucial for genetic counseling and risk management. We so...

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Ngā kaituhi matua:	Nihat B. Agaoglu, Brittany L. Bychkovsky, Carolyn Horton, Min-Tzu Lo, Linda Polfus, Cassidy Carraway, Parichehr Hemyari, Colin Young, Marcy E. Richardson, Rochelle Scheib, Judy E. Garber, Huma Q. Rana
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2024-01-01
Rangatū:	Genetics in Medicine Open
Ngā marau:	Breast cancer Genetics Germline Hereditary cancer Multiple pathogenic variants
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2949774424009750
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!