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The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6

The Hippo signaling pathway regulates tissue growth in Drosophila through the transcriptional coactivator Yorkie (Yki). How Yki activates target gene transcription is poorly understood. Here, we identify Nuclear receptor coactivator 6 (Ncoa6), a subunit of the Trithorax-related (Trr) histone H3 lysi...

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Principais autores: Yun Qing, Feng Yin, Wei Wang, Yonggang Zheng, Pengfei Guo, Frederick Schozer, Hua Deng, Duojia Pan
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2014-07-01
Serier:eLife
Fag:
Hippo signaling
transcription factor
growth control
histone methylation
Online adgang:https://elifesciences.org/articles/02564
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