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Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19

A high incidence of secondary Klebsiella pneumoniae and Staphylococcus aureus infection were observed in patients with severe COVID-19. The cause of this predisposition to infection is unclear. Our data demonstrate consumption of complement in acute COVID-19 patients reflected by low levels of C3, C...

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Principais autores: Youssif M. Ali, Nicholas J. Lynch, Priyanka Khatri, Ifeoluwa E. Bamigbola, Andrew C. Y. Chan, Munehisa Yabuki, Gregory A. Demopulos, Jonathan L. Heeney, Sumita Pai, Helen Baxendale, Wilhelm J. Schwaeble
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Immunology
Fag:
K. pneumoniae
COVID-19
SARS-CoV-2
complement system
bacterial infection
S. aureus
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.841759/full
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