JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency

Obstructive arterial diseases, including supravalvular aortic stenosis (SVAS), atherosclerosis, and restenosis, share 2 important features: an abnormal or disrupted elastic lamellae structure and excessive smooth muscle cells (SMCs). However, the relationship between these pathological features is p...

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Detalhes bibliográficos

Principais autores:	Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, Ashish Misra, George Tellides, Robert K. Riemer, Zsolt Urban, Caroline Kinnear, James Ellis, Seema Mital, Robert Mecham, Kathleen A. Martin, Daniel M. Greif
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2022-03-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Vascular biology
Acesso em linha:	https://doi.org/10.1172/JCI142338
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