Benzodioxin-Annulated Naphthalimides as Potent DNA Replication Stress Inducers with Dual p53-Dependent and Independent Antitumor Activity

<b>Background/Objectives:</b> The development of small-molecule agents that selectively target DNA replication remains a central strategy in anticancer drug discovery. In this study, we report the biological characterization of a novel 6-nitro-benzodioxin-naphthalimide (NI) derivative (compound <b>5...

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Ngā kaituhi matua:	Zlatina Vlahova, Lazar Lazarov, Maria Petrova, Shazie Yusein-Myashkova, Monika Mutovska, Stanimir Stoyanov, Yulian Zagranyarski, Iva Ugrinova
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2026-01-01
Rangatū:	Pharmaceutics
Ngā marau:	naphthalimide benzodioxin DNA damage cell cycle arrest apoptosis p53
Urunga tuihono:	https://www.mdpi.com/1999-4923/18/2/167
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!