Benzodioxin-Annulated Naphthalimides as Potent DNA Replication Stress Inducers with Dual p53-Dependent and Independent Antitumor Activity

<b>Background/Objectives:</b> The development of small-molecule agents that selectively target DNA replication remains a central strategy in anticancer drug discovery. In this study, we report the biological characterization of a novel 6-nitro-benzodioxin-naphthalimide (NI) derivative (compound <b>5...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Zlatina Vlahova, Lazar Lazarov, Maria Petrova, Shazie Yusein-Myashkova, Monika Mutovska, Stanimir Stoyanov, Yulian Zagranyarski, Iva Ugrinova
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2026-01-01
Цуврал:	Pharmaceutics
Нөхцлүүд:	naphthalimide benzodioxin DNA damage cell cycle arrest apoptosis p53
Онлайн хандалт:	https://www.mdpi.com/1999-4923/18/2/167
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!