Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis

Abstract Background A key challenge in cancer immunotherapy is that tumor vaccines formulated with conventional aluminum adjuvants often fail to elicit potent cellular immunity and sustained antitumor responses. Glycyrrhizae polysaccharides (NGUP), characterized by significant immunomodulation, mult...

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主要な著者:	Xiaopan Yao, Keqing Zhang, XiaoKun Zhang, Shengxin Lu, Jinyuan Hu, Yuexuan Wang, Jiayi Lin, Ye Wu, Weidong Zhang, Hongzhuan Chen, Xia Liu, Bei Wang, Xin Luan
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-11-01
シリーズ:	Journal of Experimental & Clinical Cancer Research
主題:	Cancer immunotherapy Vaccine adjuvants Antigen cross-presentation Tumor antigen-specific T cells Glycyrrhizae polysaccharides
オンライン･アクセス:	https://doi.org/10.1186/s13046-025-03601-6
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