Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis

Abstract Background A key challenge in cancer immunotherapy is that tumor vaccines formulated with conventional aluminum adjuvants often fail to elicit potent cellular immunity and sustained antitumor responses. Glycyrrhizae polysaccharides (NGUP), characterized by significant immunomodulation, mult...

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Hauptverfasser:	Xiaopan Yao, Keqing Zhang, XiaoKun Zhang, Shengxin Lu, Jinyuan Hu, Yuexuan Wang, Jiayi Lin, Ye Wu, Weidong Zhang, Hongzhuan Chen, Xia Liu, Bei Wang, Xin Luan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Journal of Experimental & Clinical Cancer Research
Schlagworte:	Cancer immunotherapy Vaccine adjuvants Antigen cross-presentation Tumor antigen-specific T cells Glycyrrhizae polysaccharides
Online-Zugang:	https://doi.org/10.1186/s13046-025-03601-6
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