The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

Abstract Background KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at multiple levels. However, the role of KSRP in clear cell renal cell ca...

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Detalhes bibliográficos

Principais autores:	Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen, Ming-Hsien Chien
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-08-01
Colecção:	Journal of Biomedical Science
Assuntos:	ccRCC Progression KSRP NEDD4L EMT
Acesso em linha:	https://doi.org/10.1186/s12929-023-00949-9
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