Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage
Abstract Background The propensity for off-target activity of Streptococcus pyogenes Cas9 (SpCas9) has been considerably decreased by rationally engineered variants with increased fidelity (eSpCas9; SpCas9-HF1). However, a subset of targets still generate considerable off-target effects. To deal spe...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2017-10-01
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| coleção: | Genome Biology |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s13059-017-1318-8 |
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